Unraveling chromatin organization
نویسندگان
چکیده
منابع مشابه
Chromatin Organization
Although the Victorian proverb ‘‘everything in its place and a place for everything’’ is meant for orderly households, it could just as easily describe the organization of eukaryotic genomes. This issue’s Select profiles articles that reveal new insights into how DNA is packaged and partitioned into three-dimensional (3D) structures throughout the life of a cell, shedding new light on how inter...
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The poster shows the general steps in chromatin assembly and the diversity of chromatin organization. At each step, variation in the basic constituents of chromatin leads to the establishment of distinct final structures. The left-hand column of text provides examples of such variation; the right-hand column lists stimulatory factors that can promote progression through the assembly steps. Asse...
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Splicing is a predominantly co-transcriptional process that has been shown to be tightly coupled to transcription. Chromatin structure is a key factor that mediates this functional coupling. In light of recent evidence that shows the importance of higher order chromatin organization in the coordination and regulation of gene expression, we discuss here the possible roles of long-range chromatin...
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Recent developments in technology have made it possible to create high resolution genome-wide maps of histone marks, DNA binding proteins and physical interactions along genomic regions. Chromatin features are found together in different combinations, dividing the genome up into domains with distinct functional properties. Microscopy and chromatin conformation capture techniques have shown that...
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1 Dipartimento di Fisica, INFN Sezione di Napoli, CNR-SPIN, Universita’ di Napoli Federico II, Napoli, Italy 2 Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich, UK 3 CNR Institute of Genetics and Biophysics “Buzzati Traverso”, Naples, Italy 4 M. Delbrück Center for Molecular Medicine, Berlin Institute for Medical Systems Biology, Berlin-Buch, Germany *Corresp...
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2005
ISSN: 1545-9993,1545-9985
DOI: 10.1038/nsmb0105-6